ICD-10 Code F33.3 – Major depressive disorder, recurrent, severe with psychotic symptoms (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F33.3 – Major depressive disorder, recurrent, severe with psychotic symptoms
What it is
Use this code for a recurrent major depressive disorder episode that is severe and includes psychotic symptoms. The psychosis occurs with the depressive illness, not as a separate primary psychotic disorder.
Clinical signs
Patients may have profound low mood, marked loss of interest, and major functional impairment, along with delusions or hallucinations. Clinical features vary; refer to documentation.
When to use this code
Assign F33.3 when the record clearly documents recurrent major depressive disorder with current severe symptoms and psychotic features. Use it when the clinician links the psychotic symptoms to the depressive episode and notes a prior depressive episode history.
Do not use for
Do not use this code if psychotic symptoms are not documented, or if the diagnosis is a single depressive episode. Check documentation when the chart suggests schizoaffective disorder, schizophrenia, or another primary psychotic condition.
Coding tip
Verify that the note supports both recurrence and psychotic features before coding F33.3.