ICD-10 Code E75.22 – Gaucher disease (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E75.22 – Gaucher disease
What it is
E75.22 identifies Gaucher disease, an inherited lysosomal storage disorder caused by deficient glucocerebrosidase activity. It leads to accumulation of glucocerebroside in tissues, especially the spleen, liver, bone marrow, and sometimes the nervous system.
Clinical signs
Common findings include splenomegaly, hepatomegaly, anemia, thrombocytopenia, bone pain, and fractures. Clinical features vary; refer to documentation for neurologic involvement or subtype details.
When to use this code
Use this code when the record clearly documents Gaucher disease as the diagnosis, whether confirmed by genetic, enzymatic, or specialist evaluation. Apply it for encounters focused on disease monitoring, complication assessment, or ongoing management of the condition. If the subtype is documented, code it only when the record supports that specificity.
Do not use for
Do not use this code for nonspecific hepatosplenomegaly, anemia, or bone pain without documented Gaucher disease. Check documentation if the chart mentions a storage disorder but does not name Gaucher disease.
Coding tip
Confirm the diagnosis is explicitly stated in the provider record before assigning E75.22.