ICD-10 Code E70.21 – Tyrosinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E70.21 – Tyrosinemia
What it is
E70.21 identifies tyrosinemia, an inherited disorder of tyrosine metabolism. It is used when documentation states tyrosinemia without a more specific subtype.
Clinical signs
Clinical features vary; refer to documentation. Standard references describe liver, kidney, or neurologic involvement in some patients, and the diagnosis is usually confirmed by metabolic and genetic evaluation.
When to use this code
Use E70.21 when the provider documents tyrosinemia as the diagnosis, especially in metabolic or genetic records. Apply it for confirmed disease, suspected inherited disorder being evaluated, or follow-up care tied to that diagnosis. If a subtype is documented, code the more specific option instead.
Do not use for
Do not use this code for elevated tyrosine alone, nonspecific amino acid abnormalities, or liver disease without documented tyrosinemia. Check documentation if the record only mentions screening results or a family history.
Coding tip
Confirm the exact tyrosinemia type in the chart before coding, because a more specific code may be available.