ICD-10 Code E25.0 – Congenital adrenogenital disorders associated with enzyme deficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E25.0 – Congenital adrenogenital disorders associated with enzyme deficiency
What it is
This code identifies a group of inherited adrenal disorders caused by enzyme deficiency. These conditions disrupt normal adrenal hormone production and can affect sexual development.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include ambiguous genitalia, early virilization, or other signs of abnormal androgen excess present from birth or early childhood.
When to use this code
Use E25.0 when the provider documents a congenital adrenogenital disorder due to a specific enzyme deficiency. It is appropriate for confirmed hereditary adrenal enzyme defects with genital or endocrine effects. If the record only says “adrenal disorder” or “hyperandrogenism,” check documentation before assigning this code.
Do not use for
Do not use this code for acquired adrenal disorders, nonspecific endocrine abnormalities, or cases without documented enzyme deficiency. Check documentation if the note does not clearly state a congenital adrenogenital disorder.
Coding tip
Code E25.0 only when the congenital enzyme-deficiency cause is documented, not when the record is vague or incomplete.