ICD-10 Code E08.351 – Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema (2026): Diagnosis, Symptoms & Billing Guide

The ICD-10 code for Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema is E08.351.
2026 ICD-10-CM Diagnosis Code E08.351 – Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema

What it is

This code identifies diabetes caused by another underlying condition, with eye damage showing proliferative diabetic retinopathy and macular edema. Use it when the record links the diabetes to a secondary cause and documents both retinal proliferation and macular swelling.

Clinical signs

Clinical features vary; refer to documentation. Typical findings include diabetic retinal neovascularization and evidence of macular edema on eye examination or imaging, with vision changes possible.

When to use this code

Use this code when the provider documents diabetes mellitus due to an underlying condition and specifically identifies proliferative diabetic retinopathy with macular edema. The eye condition must be tied to the diabetic disease process in the chart. If the cause of diabetes or the retinal stage is unclear, check documentation before coding.

Do not use for

Do not use this code for diabetes not caused by another condition, or for diabetic retinopathy without proliferative changes or macular edema. Check documentation if the eye findings are unspecified.

Coding tip

Verify both the secondary diabetes etiology and the exact retinopathy stage before assigning E08.351.

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