ICD-10 Code D76.2 – Hemophagocytic syndrome, infection-associated (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D76.2 – Hemophagocytic syndrome, infection-associated
What it is
D76.2 identifies hemophagocytic syndrome triggered by an infection. It refers to an excessive inflammatory response in which immune cells become overactive and may damage blood cells and organs.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include persistent fever, enlarged spleen, cytopenias, and evidence of systemic inflammation or organ involvement.
When to use this code
Use D76.2 when the provider documents hemophagocytic syndrome as infection-associated or infection-triggered. Code it when the record links the syndrome to an infectious cause, even if the specific pathogen is still being evaluated. If the note only says “hemophagocytic syndrome” without an infectious association, check documentation.
Do not use for
Do not use this code for hemophagocytic syndrome without an infection-related cause. Also avoid it when the chart documents a different inflammatory, hematologic, or febrile condition instead.
Coding tip
Code the underlying infection separately when documented, and confirm that the provider explicitly links it to the hemophagocytic syndrome.