ICD-10 Code C83.38 – Diffuse large B-cell lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C83.38 – Diffuse large B-cell lymphoma, lymph nodes of multiple sites
What it is
C83.38 identifies diffuse large B-cell lymphoma involving lymph nodes at multiple sites. Use it for a documented aggressive B-cell non-Hodgkin lymphoma with nodal disease in more than one location.
Clinical signs
Clinical features vary; refer to documentation. Common findings include enlarged lymph nodes, often with systemic “B” symptoms, and pathology confirming diffuse large B-cell lymphoma.
When to use this code
Use C83.38 when the provider documents diffuse large B-cell lymphoma affecting lymph nodes of multiple sites. It fits confirmed nodal disease when the record specifies multiple lymph node regions rather than a single site.
If the note only says diffuse large B-cell lymphoma without site detail, check the chart for exact anatomic documentation before coding. Confirm the diagnosis is not being used for a history, rule-out, or other lymphoma subtype.
Do not use for
Do not use this code for diffuse large B-cell lymphoma limited to one lymph node region or for non-nodal disease. Check documentation if the record describes another lymphoma type or an unspecified site.
Coding tip
Match the code to the documented nodal distribution; “multiple sites” must be explicit or clearly supported in the record.