ICD-10 Code C54.1 – Malignant neoplasm of endometrium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C54.1 – Malignant neoplasm of endometrium
What it is
C54.1 identifies a malignant tumor arising in the endometrium, the lining of the uterus. Use it for confirmed endometrial cancer when documentation specifies the endometrium as the primary site.
Clinical signs
Common findings include abnormal uterine bleeding, especially after menopause, and pelvic pain or discharge. Diagnosis is usually supported by imaging and tissue sampling; clinical features vary, so refer to documentation.
When to use this code
Use C54.1 when the provider documents primary endometrial malignancy, including carcinoma of the uterine lining. It is appropriate for pathology-confirmed cancer, oncology follow-up for the active condition, or definitive diagnosis recorded in the chart. Check documentation if the site is described only as uterus or corpus uteri.
Do not use for
Do not use this code for benign endometrial conditions, hyperplasia, or cancer that is documented as arising in another uterine site. If the record does not clearly identify the endometrium, check documentation.
Coding tip
Code the most specific uterine site documented, and verify whether the malignancy is primary or metastatic before assigning C54.1.