ICD-10 Code B33.4 – Hantavirus (cardio)-pulmonary syndrome [HPS] [HCPS] (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code B33.4 – Hantavirus (cardio)-pulmonary syndrome [HPS] [HCPS]
What it is
B33.4 identifies hantavirus cardiopulmonary syndrome, a serious viral illness caused by hantavirus infection. It involves acute respiratory and cardiovascular compromise and is documented when this specific syndrome is diagnosed.
Clinical signs
Clinical features vary; refer to documentation. Typical findings include fever, myalgia, cough, and rapidly worsening shortness of breath, often with evidence of pulmonary involvement and hemodynamic instability.
When to use this code
Use B33.4 when the provider documents hantavirus cardiopulmonary syndrome or HCPS/HPS as the confirmed diagnosis. Apply it for cases where the syndrome is the focus of care, including hospital evaluation for acute respiratory failure related to hantavirus infection.
Do not use for
Do not use this code for nonspecific viral illness or for suspected hantavirus without confirmed syndrome documentation. Check documentation if the record only states exposure, rule-out infection, or another viral diagnosis.
Coding tip
Code the documented syndrome exactly as stated and confirm whether the provider specifies HPS, HCPS, or another hantavirus diagnosis.