ICD-10 Code E72.20 – Disorder of urea cycle metabolism, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.20 – Disorder of urea cycle metabolism, unspecified
What it is
This code identifies an unspecified disorder affecting the urea cycle, the body process that helps remove ammonia from the blood. Use it when the record confirms a urea cycle metabolic disorder but does not name the exact type.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include recurrent hyperammonemia, poor feeding, vomiting, lethargy, confusion, or neurologic decline, especially in infants or during metabolic stress.
When to use this code
Use E72.20 when the provider documents a urea cycle disorder without specifying the enzyme defect or subtype. It also fits when the chart notes a confirmed inherited disorder of ammonia detoxification but the exact diagnosis is not available. Check documentation if the record is ambiguous.
Do not use for
Do not use this code for hyperammonemia alone without a documented urea cycle disorder. Also avoid it when a more specific urea cycle diagnosis is stated in the record.
Coding tip
Choose the unspecified code only after reviewing the chart for a more detailed metabolic diagnosis.