ICD-10 Code E72.11 – Homocystinuria (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.11 – Homocystinuria
What it is
Homocystinuria is an inherited metabolic disorder in which the body cannot properly process homocysteine. It leads to abnormal buildup of homocysteine and related compounds.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include lens dislocation, developmental delay, skeletal abnormalities, and an increased risk of thromboembolic events.
When to use this code
Use E72.11 when the provider documents homocystinuria or a confirmed homocysteine metabolism disorder. It is appropriate for established diagnoses in outpatient, inpatient, or problem-list documentation. Code it when the condition is the reason for evaluation, monitoring, or ongoing care.
Do not use for
Do not use this code for isolated elevated homocysteine without a documented diagnosis of homocystinuria. Check documentation if the record only mentions suspected metabolic disorder or a family history.
Coding tip
Confirm the provider’s exact diagnosis wording, because homocystinuria and nonspecific hyperhomocysteinemia are not interchangeable.