ICD-10 Code E71.12 – Disorders of propionate metabolism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E71.12 – Disorders of propionate metabolism
What it is
E71.12 identifies inherited disorders that impair propionate metabolism, a pathway the body uses to break down certain proteins and fats. These conditions can lead to toxic metabolite buildup and metabolic instability.
Clinical signs
Clinical features vary; refer to documentation. Common findings in standard references include poor feeding, vomiting, lethargy, developmental delay, and episodes of metabolic decompensation, especially in infancy or during illness.
When to use this code
Use this code when the record specifically documents a disorder of propionate metabolism, such as propionic acidemia or another confirmed propionate pathway defect. Apply it for confirmed diagnoses, genetic/metabolic workups, or specialist assessments that name the condition. Check documentation if the chart only notes an abnormal newborn screen or suspected metabolic disorder.
Do not use for
Do not use E71.12 for nonspecific acidosis, vomiting, or failure to thrive without a documented propionate metabolism disorder. If the diagnosis is only suspected or ruled out, check documentation for a more accurate code.
Coding tip
Look for the exact metabolic diagnosis name in the assessment, problem list, or specialist note before assigning E71.12.