ICD-10 Code E70.321 – Tyrosinase positive oculocutaneous albinism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E70.321 – Tyrosinase positive oculocutaneous albinism
What it is
This code identifies a form of oculocutaneous albinism caused by reduced melanin production despite some tyrosinase activity. It describes a genetic pigment disorder affecting skin, hair, and eyes.
Clinical signs
Typical findings include generalized hypopigmentation, light hair and skin, and ocular involvement such as reduced visual acuity, nystagmus, or photophobia. Clinical features vary; refer to documentation.
When to use this code
Use this code when the record specifically documents tyrosinase positive oculocutaneous albinism or an equivalent diagnosis. It is also appropriate when the clinician confirms this subtype after genetic, ophthalmic, or dermatologic evaluation.
Do not code it from vague notes such as “albinism” alone unless the subtype is clearly stated. Check documentation if the chart only mentions pigment loss without a definitive diagnosis.
Do not use for
Do not use this code for other albinism types, isolated ocular albinism, or nonspecific hypopigmentation. Check documentation if the record does not identify the tyrosinase-positive subtype.
Coding tip
Look for the exact subtype in the assessment, problem list, or specialist note before assigning E70.321.