ICD-10 Code E23.1 – Drug-induced hypopituitarism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E23.1 – Drug-induced hypopituitarism
What it is
E23.1 identifies hypopituitarism caused by a drug or medication effect. Use it when pituitary hormone deficiency is documented as drug-induced, not from a primary pituitary disorder.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include symptoms of pituitary hormone deficiency, such as fatigue, menstrual changes, decreased libido, or other endocrine abnormalities linked to pituitary underactivity.
When to use this code
Use this code when the provider states that a medication or drug exposure caused hypopituitarism. It fits cases where the record links pituitary dysfunction to an adverse drug effect or iatrogenic cause. Check documentation for the specific agent and causal wording.
Do not use for
Do not use it for hypopituitarism with no documented drug cause, or when the condition is due to a pituitary tumor, surgery, radiation, or another non-drug etiology. Check documentation if the cause is unclear.
Coding tip
Code the drug-induced cause only when the record clearly supports causation; otherwise, query for clarification.