ICD-10 Code E22.1 – Hyperprolactinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E22.1 – Hyperprolactinemia
What it is
Hyperprolactinemia means an abnormally high prolactin level in the blood. It is a diagnosis code used when documentation identifies excess prolactin, whether due to a pituitary disorder, medication effect, or another cause.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include menstrual irregularity, galactorrhea, infertility, decreased libido, or symptoms related to a pituitary mass if present.
When to use this code
Use E22.1 when the provider documents hyperprolactinemia, elevated prolactin, or prolactin excess as the assessed condition. It may also apply when the record links the finding to a pituitary adenoma or another documented cause. Code the documented diagnosis, not a suspected explanation.
Do not use for
Do not use this code for isolated abnormal lab results without a documented diagnosis. Check documentation if the record instead supports a pituitary tumor, medication adverse effect, or another endocrine disorder.
Coding tip
Query for the underlying cause when the record only shows elevated prolactin, and code the cause separately if it is documented.