ICD-10 Code E22.0 – Acromegaly and pituitary gigantism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E22.0 – Acromegaly and pituitary gigantism
What it is
E22.0 identifies excess growth hormone causing acromegaly in adults or pituitary gigantism when it occurs before epiphyseal closure. Use it for the endocrine disorder itself, not for unrelated pituitary findings.
Clinical signs
Typical findings include enlarged hands and feet, coarse facial features, and soft-tissue overgrowth. Clinical features vary; refer to documentation for the specific diagnosis and whether the condition is described as acromegaly or pituitary gigantism.
When to use this code
Use E22.0 when the provider documents acromegaly, pituitary gigantism, or growth hormone excess with compatible clinical diagnosis. It also fits confirmed cases being followed after evaluation of pituitary disease. If the note only says “pituitary tumor” or “elevated growth hormone,” check documentation before assigning the code.
Do not use for
Do not use this code for general pituitary disorders, benign pituitary neoplasms, or nonspecific endocrine symptoms without a documented diagnosis. Check documentation if the record describes a mass, hyperprolactinemia, or another hormone disorder instead.
Coding tip
Code E22.0 only when the provider clearly links the condition to acromegaly or pituitary gigantism, and query if the documentation is incomplete.