ICD-10 Code E05.1 – Thyrotoxicosis with toxic single thyroid nodule (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E05.1 – Thyrotoxicosis with toxic single thyroid nodule
What it is
E05.1 identifies thyrotoxicosis caused by one toxic thyroid nodule. The nodule produces excess thyroid hormone and leads to hyperthyroid symptoms.
Clinical signs
Clinical features may include weight loss, heat intolerance, tremor, palpitations, and a visible or palpable thyroid nodule. Clinical features vary; refer to documentation.
When to use this code
Use this code when the record clearly states thyrotoxicosis due to a single toxic thyroid nodule. It fits confirmed toxic adenoma or an autonomously functioning solitary nodule causing hyperthyroidism. Do not use it when the documentation only says hyperthyroidism without a nodular cause.
Do not use for
Do not use for diffuse toxic goiter, toxic multinodular goiter, or nonspecific thyrotoxicosis. Check documentation if the nodule is present but not identified as the source.
Coding tip
Assign E05.1 only when the provider links the thyrotoxicosis to a single toxic nodule.