ICD-10 Code D81.30 – Adenosine deaminase deficiency, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D81.30 – Adenosine deaminase deficiency, unspecified
What it is
D81.30 identifies adenosine deaminase deficiency when the record does not specify the exact form. It is a rare inherited immune disorder that can cause severe combined immunodeficiency.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include recurrent serious infections, poor growth, and lymphopenia, but you should code only what is documented.
When to use this code
Use D81.30 when the provider documents adenosine deaminase deficiency without further detail. It also fits when the chart confirms ADA deficiency but does not specify a subtype or related immunodeficiency classification. If the record names a more specific diagnosis, code that instead.
Do not use for
Do not use this code for other combined immunodeficiencies, acquired immune disorders, or nonspecific “immune deficiency” notes. Check documentation if the diagnosis is unclear or if another hereditary immunodeficiency is stated.
Coding tip
Code the condition exactly as documented and avoid assuming severity, subtype, or associated complications.