ICD-10 Code D75.81 – Myelofibrosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D75.81 – Myelofibrosis
What it is
Myelofibrosis is a bone marrow disorder in which scar tissue builds up and disrupts normal blood cell production. You use this code for the diagnosis of myelofibrosis when it is documented by the clinician.
Clinical signs
Clinical features vary; refer to documentation. Common findings can include anemia, fatigue, splenomegaly, and abnormal blood counts, but you should code only what is documented as myelofibrosis.
When to use this code
Use D75.81 when the provider documents myelofibrosis as the confirmed diagnosis, including primary or secondary forms if not otherwise specified. It may appear in hematology notes, discharge summaries, or problem lists when the condition is being actively evaluated or managed.
Do not use for
Do not use this code for nonspecific anemia, splenomegaly, or other blood count abnormalities without a documented diagnosis of myelofibrosis. Check documentation if the record only mentions marrow fibrosis or another specific myeloproliferative disorder.
Coding tip
Confirm the exact provider wording; if the note identifies an underlying condition, code that diagnosis as well when supported.