ICD-10 Code D72.823 – Leukemoid reaction (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D72.823 – Leukemoid reaction
What it is
D72.823 identifies a leukemoid reaction, which is a marked increase in white blood cells that is not due to leukemia. It usually reflects a strong response to infection, inflammation, stress, or another underlying condition.
Clinical signs
Clinical features vary; refer to documentation. You may see very high leukocyte counts with a shift toward immature granulocytes, often alongside evidence of an acute illness or inflammatory process.
When to use this code
Use this code when the provider documents leukemoid reaction or clearly describes a reactive, nonmalignant leukocytosis. It may apply when the elevated white count is attributed to infection, severe inflammation, tissue injury, or another trigger rather than a hematologic cancer.
Do not infer the diagnosis from lab results alone if the record does not state leukemoid reaction. If the note only says “leukocytosis,” check documentation for the specific cause before coding.
Do not use for
Do not use this code for leukemia, unspecified leukocytosis, or transient white count changes without a documented leukemoid reaction. Check documentation if the cause is unclear.
Coding tip
Code the underlying condition first when documented, and report D72.823 only when the reactive leukemoid reaction is specifically identified.