ICD-10 Code D72.822 – Plasmacytosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D72.822 – Plasmacytosis
What it is
Plasmacytosis means an increased number of plasma cells in blood or tissues. It is a descriptive diagnosis, so you should code it when the record specifically documents this finding.
Clinical signs
Clinical features vary; refer to documentation. You may see plasma cell proliferation noted on pathology, bone marrow, or other tissue evaluation, but the code itself reflects the documented finding rather than a specific cause.
When to use this code
Use D72.822 when the provider documents plasmacytosis as the diagnosis or a confirmed morphologic finding. It may appear in biopsy, marrow, or hematology reports when plasma cells are increased and no more specific diagnosis is recorded.
If the chart names a separate underlying disorder, code that condition instead or in addition, as directed by the record. Check documentation when the term appears only as a differential consideration or incidental comment.
Do not use for
Do not use this code for plasma cell neoplasms, multiple myeloma, or other specific hematologic disorders unless the provider also documents plasmacytosis. Do not assign it for suspected findings without confirmation.
Coding tip
Code the documented finding exactly and look for a more specific diagnosis before defaulting to D72.822.