ICD-10 Code D72.12 – Drug rash with eosinophilia and systemic symptoms syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D72.12 – Drug rash with eosinophilia and systemic symptoms syndrome
What it is
D72.12 identifies drug rash with eosinophilia and systemic symptoms syndrome, also called DRESS. It describes a serious delayed reaction to a medication that can affect the skin and internal organs.
Clinical signs
Typical findings include widespread rash, fever, facial swelling, lymphadenopathy, and eosinophilia. Clinical features vary; refer to documentation for organ involvement such as liver, kidney, or lung abnormalities.
When to use this code
Use this code when the record documents DRESS syndrome or a drug-induced hypersensitivity reaction with systemic involvement. It is appropriate when the clinician links the reaction to a medication and records the syndrome clearly. Check documentation if the chart only says “drug rash” without systemic features.
Do not use for
Do not use D72.12 for simple allergic rash, urticaria, or nonspecific adverse drug effects without eosinophilia and systemic symptoms. If the diagnosis is uncertain, check documentation.
Coding tip
Capture the causative drug and any documented organ involvement, because these details support accurate sequencing and reporting.