ICD-10 Code D64.81 – Anemia due to antineoplastic chemotherapy (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D64.81 – Anemia due to antineoplastic chemotherapy
What it is
This code identifies anemia caused by antineoplastic chemotherapy. Use it when the record shows the anemia is a direct effect of cancer treatment, not from another cause.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include pallor, fatigue, weakness, and reduced exercise tolerance, along with provider confirmation that chemotherapy is the cause.
When to use this code
Use D64.81 when the clinician documents anemia due to chemotherapy or links the anemia to antineoplastic treatment. It is appropriate for encounters where the anemia is being evaluated, monitored, or managed as a chemotherapy adverse effect.
If the chart only notes anemia in a patient receiving chemotherapy, check documentation for a causal relationship before assigning this code. Code the malignancy and any other documented treatment effects as applicable.
Do not use for
Do not use this code for anemia from blood loss, nutritional deficiency, chronic disease, or another specified cause. Check documentation if the anemia is not clearly attributed to antineoplastic chemotherapy.
Coding tip
Link the anemia to chemotherapy in the provider note; without that connection, you should not assume D64.81.