ICD-10 Code D56.2 – Delta-beta thalassemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D56.2 – Delta-beta thalassemia
What it is
Delta-beta thalassemia is an inherited hemoglobin disorder caused by reduced production of both delta and beta globin chains. It can lead to a thalassemia pattern with anemia and abnormal hemoglobin composition.
Clinical signs
Clinical features vary; refer to documentation. Patients may have mild to moderate anemia, microcytosis, fatigue, or may be asymptomatic and identified on hemoglobin studies or family screening.
When to use this code
Use D56.2 when the record specifically documents delta-beta thalassemia or a confirmed combined delta-beta globin chain defect. It also fits cases noted as an inherited hemoglobinopathy with this exact subtype, when the diagnosis is established by the clinician.
Do not use for
Do not use this code for other thalassemia types, such as alpha thalassemia or beta thalassemia, unless delta-beta thalassemia is clearly documented. Check documentation if the chart only says “thalassemia” or “anemia.”
Coding tip
Code the specific hemoglobin disorder only when the provider names delta-beta thalassemia; otherwise, query for clarification.