ICD-10 Code D56.0 – Alpha thalassemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D56.0 – Alpha thalassemia
What it is
Alpha thalassemia is an inherited hemoglobin disorder caused by reduced or absent alpha-globin chain production. It can range from silent carrier status to severe anemia, depending on how many alpha-globin genes are affected.
Clinical signs
Clinical features vary; refer to documentation. Patients may have microcytic anemia, pallor, fatigue, or a history of hemolysis. More severe forms can present with jaundice, splenomegaly, or abnormal newborn screening results.
When to use this code
Use this code when the provider documents alpha thalassemia, alpha-thalassemia trait, or a confirmed alpha-globin chain deficiency. It also fits cases identified by genetic testing or hematology evaluation when the diagnosis is clearly stated. If the record only says “thalassemia” without type, check documentation.
Do not use for
Do not use this code for beta thalassemia or unspecified thalassemia. Avoid it when anemia is documented without confirmation of alpha thalassemia.
Coding tip
Match the code to the exact thalassemia type documented; if the subtype is unclear, query the provider.