ICD-10 Code C85.28 – Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C85.28 – Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites
What it is
This code identifies a specific aggressive B-cell lymphoma arising in the mediastinum, often involving thymic tissue and lymph nodes at multiple sites. Use it when the documentation names this exact lymphoma.
Clinical signs
Patients may present with a mediastinal mass, chest pressure, cough, or shortness of breath. Clinical features vary; refer to documentation and pathology confirming mediastinal large B-cell lymphoma with nodal involvement.
When to use this code
Use C85.28 when the provider documents mediastinal (thymic) large B-cell lymphoma and specifies lymph nodes of multiple sites. This is appropriate for confirmed diagnoses in inpatient, outpatient, or oncology records. If the site or lymphoma type is unclear, check documentation before coding.
Do not use for
Do not use this code for other non-Hodgkin lymphomas, unspecified lymphoma, or mediastinal masses without a confirmed lymphoma diagnosis. Do not assume multiple-site nodal disease unless it is documented.
Coding tip
Code the lymphoma only when both the mediastinal type and multiple-site nodal involvement are clearly documented.