ICD-10 Code C81.39 – Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.39 – Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
What it is
This code identifies lymphocyte-depleted Hodgkin lymphoma arising in extranodal or solid organ sites. Use it when the record specifies this histologic subtype and the involved site is outside lymph nodes.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include a mass or organ involvement confirmed by pathology, imaging, or biopsy, with the lymphoma subtype explicitly stated in the report.
When to use this code
Use this code when the provider documents lymphocyte-depleted Hodgkin lymphoma involving an extranodal site or solid organ, such as liver, lung, or other non-nodal tissue. It is appropriate when the diagnosis is confirmed and the site is clearly identified in the chart.
If the record only says Hodgkin lymphoma without subtype or site detail, check documentation before assigning C81.39. Code the most specific diagnosis available from pathology, oncology notes, or discharge summaries.
Do not use for
Do not use this code for nodal Hodgkin lymphoma, unspecified Hodgkin lymphoma, or other lymphoma subtypes. Check documentation if the site is not extranodal or if the pathology does not confirm lymphocyte depletion.
Coding tip
Match both the subtype and the site in the pathology or oncology note before coding C81.39.