ICD-10 Code C81.25 – Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.25 – Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
What it is
C81.25 identifies mixed cellularity Hodgkin lymphoma involving lymph nodes in the inguinal region and lower limb. Use it when the diagnosis specifies this Hodgkin lymphoma subtype and the nodal site is documented.
Clinical signs
Clinical features vary; refer to documentation. Hodgkin lymphoma commonly presents with enlarged lymph nodes, sometimes with systemic “B” symptoms such as fever, night sweats, or weight loss.
When to use this code
Use this code when the provider documents mixed cellularity Hodgkin lymphoma and specifies involvement of inguinal or lower-limb lymph nodes. It is also appropriate when pathology or oncology notes clearly confirm that site and subtype. Check documentation if the site is unclear or if only generalized lymphoma is recorded.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, unspecified Hodgkin lymphoma, or non-Hodgkin lymphoma. If the record does not confirm the inguinal or lower-limb nodal site, check documentation.
Coding tip
Assign the code only when both the mixed cellularity subtype and the specific lymph node region are documented.