ICD-10 Code F18.221 – Inhalant dependence with intoxication delirium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F18.221 – Inhalant dependence with intoxication delirium
What it is
F18.221 identifies inhalant dependence when the patient is also experiencing delirium caused by intoxication. Use it when the record shows both ongoing inhalant dependence and an acute confused state from recent inhalant use.
Clinical signs
Common findings include disorientation, impaired attention, altered awareness, and fluctuating cognition during intoxication. Clinical features vary; refer to documentation for evidence of delirium and inhalant dependence.
When to use this code
Use this code when the provider documents inhalant dependence together with intoxication delirium. The note should support both the substance use disorder and the delirium being linked to inhalant intoxication. If the chart only says intoxication or only says dependence, check documentation before assigning this code.
Do not use for
Do not use it for inhalant abuse, simple intoxication without delirium, or delirium from another cause. Check documentation if the record does not clearly state dependence.
Coding tip
Assign F18.221 only when the provider explicitly documents both dependence and intoxication delirium.