ICD-10 Code F12.221 – Cannabis dependence with intoxication delirium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F12.221 – Cannabis dependence with intoxication delirium
What it is
F12.221 identifies cannabis dependence accompanied by intoxication delirium. Use it when cannabis use disorder is severe enough to show dependence and the patient is acutely delirious from intoxication.
Clinical signs
Delirium presents with disturbed attention, confusion, and a reduced awareness of the environment. Clinical features vary; refer to documentation for evidence of cannabis intoxication and dependence.
When to use this code
Use this code when the record clearly documents cannabis dependence and a current delirium caused by intoxication. The delirium must be linked to cannabis use, not another substance or medical condition.
Assign it from provider documentation that supports both the dependence diagnosis and the intoxication delirium. Check documentation if the chart only shows cannabis use, intoxication, or altered mental status without delirium.
Do not use for
Do not use for uncomplicated cannabis dependence, cannabis abuse, or cannabis intoxication without delirium. Also avoid it when delirium is attributed to another drug, withdrawal, or a medical cause.
Coding tip
Confirm the provider explicitly links delirium to cannabis intoxication before assigning F12.221.