ICD-10 Code E78.0 – Pure Hypercholesterolemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E78.0 – Pure hypercholesterolemia
What it is
Pure hypercholesterolemia is a lipid disorder marked by elevated cholesterol, especially LDL cholesterol, without a broader mixed lipid abnormality. Use this code when documentation specifically identifies isolated hypercholesterolemia.
Clinical signs
Patients may have no symptoms and the condition is often found on routine lipid testing. Clinical features vary; refer to documentation for the exact lipid pattern and whether the elevation is isolated.
When to use this code
Use E78.0 when the provider documents pure hypercholesterolemia, isolated hypercholesterolemia, or similar wording. It fits cases where cholesterol is the main abnormality and the record does not describe combined hyperlipidemia or secondary causes. Check documentation if the cause or lipid pattern is unclear.
Do not use for
Do not use this code for mixed hyperlipidemia, hyperglyceridemia, or secondary lipid disorders unless the record clearly supports E78.0. If the documentation does not specify isolated hypercholesterolemia, check documentation.
Coding tip
Code only when the provider explicitly documents isolated high cholesterol, not just an abnormal lipid panel.