ICD-10 Code E77.1 – Defects in glycoprotein degradation (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E77.1 – Defects in glycoprotein degradation
What it is
E77.1 identifies inherited defects in breaking down glycoproteins, leading to abnormal storage of complex molecules in cells. Use it for documented glycoprotein degradation disorders, not for general metabolic disease.
Clinical signs
Clinical features vary; refer to documentation. These disorders may present with developmental delay, organ involvement, or other signs of lysosomal storage disease, depending on the specific condition.
When to use this code
Use E77.1 when the record clearly states a defect in glycoprotein degradation or a related inherited glycoproteinosis. It is appropriate when the clinician documents this diagnosis without naming a more specific disorder. If the chart only suggests a metabolic problem, check documentation before coding.
Do not use for
Do not use this code for nonspecific abnormal laboratory findings, acquired liver disease, or unrelated carbohydrate metabolism problems. If the diagnosis is a different inherited storage disorder, code the documented condition instead.
Coding tip
Code the most specific documented lysosomal or glycoprotein disorder first; use E77.1 only when the record supports this exact diagnosis.