ICD-10 Code D73.1 – Hypersplenism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D73.1 – Hypersplenism
What it is
Hypersplenism means the spleen is overactive and removes blood cells from circulation too quickly. It is a clinical diagnosis often associated with splenomegaly and reduced blood cell counts.
Clinical signs
Common findings include an enlarged spleen and one or more low blood cell lines, such as anemia, leukopenia, or thrombocytopenia. Clinical features vary; refer to documentation.
When to use this code
Use D73.1 when the provider documents hypersplenism as the diagnosis or explains that the spleen is causing excessive sequestration or destruction of blood cells. You may also use it when hypersplenism is the stated reason for evaluation of cytopenias. Check documentation if the record only notes splenomegaly without hypersplenism.
Do not use for
Do not assign this code for simple splenomegaly alone or for low blood counts without documentation linking them to hypersplenism. If the cause is unclear, check documentation.
Coding tip
Code hypersplenism only when the provider clearly connects the spleen to the cytopenia or overactivity.