ICD-10 Code D48.2 – Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D48.2 – Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
What it is
This code identifies a growth in the peripheral nerves or autonomic nervous system whose behavior is uncertain. Use it when pathology or clinical documentation does not confirm whether the lesion is benign or malignant.
Clinical signs
Clinical features vary; refer to documentation. These lesions may present as a mass, nerve-related pain, numbness, weakness, or autonomic dysfunction depending on location and size.
When to use this code
Use D48.2 when the provider documents a neoplasm of uncertain behavior involving peripheral nerves or autonomic nerves and no definitive malignant or benign diagnosis is established. It is appropriate for confirmed tumors with indeterminate behavior on pathology or imaging. Check documentation if the anatomic site is unclear.
Do not use for
Do not use this code for clearly benign or malignant nerve tumors, or when the record identifies a different anatomic site. If the behavior is known, code the specific confirmed diagnosis instead.
Coding tip
Confirm both the nerve system involved and the tumor behavior in the report before assigning D48.2.