ICD-10 Code C96.0 – Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C96.0 – Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
What it is
C96.0 identifies disseminated Langerhans-cell histiocytosis involving multiple sites or organ systems. Use it when the record documents multifocal or multisystemic disease rather than a single localized lesion.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include lesions in more than one bone or involvement of organs such as skin, liver, spleen, or lung.
When to use this code
Use C96.0 when the provider specifies multifocal, disseminated, or multisystem Langerhans-cell histiocytosis. It also fits when the chart clearly shows disease across several anatomic sites and the diagnosis is confirmed. If the note only says “Langerhans-cell histiocytosis” without extent, check documentation before coding.
Do not use for
Do not use this code for a single localized Langerhans-cell lesion or when another histiocytosis diagnosis is documented. If the record does not confirm dissemination, check documentation.
Coding tip
Look for wording such as “multifocal,” “multisystem,” or “disseminated” in the final diagnosis before assigning C96.0.