ICD-10 Code C45.2 – Mesothelioma of pericardium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C45.2 – Mesothelioma of pericardium
What it is
C45.2 identifies malignant mesothelioma arising in the pericardium, the sac around the heart. Use this code when documentation clearly states pericardial mesothelioma.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings may include pericardial effusion, chest discomfort, dyspnea, or signs of cardiac compression, but you should code only what is documented.
When to use this code
Use C45.2 when the record specifies mesothelioma of the pericardium or malignant pericardial mesothelioma. It is appropriate for confirmed diagnoses in pathology, oncology, or discharge documentation. If the site is described only as thoracic or pleural, check documentation before assigning this code.
Do not use for
Do not use this code for pleural, peritoneal, or other mesothelioma sites. If the documentation says only “mesothelioma” without a pericardial site, check documentation rather than assuming C45.2.
Coding tip
Verify the anatomic site in the final diagnostic statement; site specificity drives correct mesothelioma coding.