ICD-10 Code L51.3 – Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code L51.3 – Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome
What it is
L51.3 identifies the overlap form of Stevens-Johnson syndrome and toxic epidermal necrolysis. Use it for severe mucocutaneous drug reaction cases that fall between the two conditions.
Clinical signs
Typical findings include widespread skin pain, blistering, and epidermal detachment with mucosal involvement. Clinical features vary; refer to documentation for the extent of body surface involvement and overlap description.
When to use this code
Use this code when the clinician documents Stevens-Johnson syndrome/toxic epidermal necrolysis overlap, SJS-TEN overlap, or similar wording. It is appropriate when the record clearly indicates a mixed presentation rather than isolated SJS or TEN. Check documentation if the diagnosis is nonspecific.
Do not use for
Do not use L51.3 for erythema multiforme, drug rash without epidermal necrolysis, or uncomplicated Stevens-Johnson syndrome alone. If the overlap is not documented, code the condition actually stated.
Coding tip
Code only when the provider explicitly documents the overlap syndrome; otherwise, query or select the more specific documented diagnosis.