ICD-10 Code J96.21 – Acute and chronic respiratory failure with hypoxia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code J96.21 – Acute and chronic respiratory failure with hypoxia
What it is
J96.21 identifies respiratory failure that is both acute and chronic, with hypoxia. It means the lungs are not supplying enough oxygen, and the condition has an acute worsening on top of an existing chronic problem.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include shortness of breath, low oxygen saturation, increased work of breathing, and the need for supplemental oxygen or ventilatory support.
When to use this code
Use this code when the record clearly states acute and chronic respiratory failure with hypoxia. It is appropriate when both the acute episode and the chronic baseline are documented, not just respiratory distress or hypoxemia alone. Check documentation if the type is unclear.
Do not use for
Do not use J96.21 for chronic respiratory failure without an acute component, or for hypoxia that is not documented as respiratory failure. If the provider documents a different type of respiratory failure, code that specific condition instead.
Coding tip
Assign J96.21 only when the provider links hypoxia to acute-on-chronic respiratory failure in the chart.