ICD-10 Code I51.81 – Takotsubo syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code I51.81 – Takotsubo syndrome
What it is
I51.81 identifies Takotsubo syndrome, a transient heart condition that mimics a heart attack. It is often linked to sudden stress and temporary left ventricular dysfunction.
Clinical signs
Patients may present with chest pain, shortness of breath, or ECG changes that resemble acute coronary syndrome. Imaging typically shows temporary apical or other regional ballooning; clinical features vary, refer to documentation.
When to use this code
Use I51.81 when the provider documents Takotsubo syndrome, stress cardiomyopathy, or broken heart syndrome. Code it when the diagnosis is confirmed in the record, even if the initial workup looked like myocardial infarction. If documentation is unclear, check documentation.
Do not use for
Do not use this code for nonspecific chest pain, acute coronary syndrome, or myocardial infarction unless Takotsubo syndrome is specifically documented. Avoid it when the record only mentions suspected stress-related symptoms.
Coding tip
Assign I51.81 only from provider documentation; if the term Takotsubo syndrome is absent, query for clarification.